Cryo-EM as a magnifying glass into the action mechanism of protein–nucleic acid complexes important for biomedicine and biotechnology

Writing genomes, metagenomes and the advent of synthetic evolution

1.“Identificación de nuevas variantes genéticas en neoplasias mieloproliferativas crónicas chr Ph- mediante secuenciación de exoma y genómica computacional” Eduard Mas Marín” (Universidad de California en Irvine, Estados Unidos) | 2. “Investigation of the differential proteome associated to CRC recurrence by proteomics analysis of FFPE tissue samples and plasma extracellular vesicles” Raquel Rejas González (Instituto de Salud Carlos lll) | 3. “Designing RNA-binding repeat proteins for splicing modulation in SMA” Laura Pérez Fernández (CIC biomaGUNE. IIS Biogipuzkoa) | 4. “Correction of pathogenic mutations associated with ALS by using PAM-less synthetic enzymes” Irati Mitxelena Balerdi (CICbioGUNE)

1. “Extracellular vesicles from hypothalamic astrocytes modify transcription factors of the leptin signaling pathway in proopiomelanocortin (POMC) neurons” Alfonso Gómez Romero, (UAM, Hospital Infantil Universitario Niño Jesús, Instituto de Investigación La Princesa) | 2. “C3G is a new regulator of liver and hepatocarcinoma metabolism. Impact on PKM2 expression” Jaime Mancebo (Departamento de Bioquímica y Biología Molecular, Facultad de Farmacia, Universidad Complutense de Madrid. IdISSC) | 3. “TRIB2 as a novel switch of glycolytic metabolism in melanoma cells” Victor Mayoral-Varo (Facultad HM de Ciencias de la Salud, Universidad Camilo José Cela. Instituto de Investigación Sanitaria HM Hospitales. IIBM-CSIC-UAM) | 4.”Galectin-3 depletion tames pro-tumoural microglia and restrains glioblastoma and brain metastasis” Rocío Talaverón (Dpto Bioquímica y Biología Molecular. Facultad de Farmacia. Universidad de Sevilla. IBiS-HUVR-CSIC-US)

1."NBusCeliac rapid test: towards non-invasive diagnosis of celiac disease". Daniel Abella López (CiQUS) | 2. “Unraveling Ageing through RNA Methylation: Age-Related Changes in m5C on mRNA”. Alba Cortés Coego (CiMUS) | 3.”Loss of mitochondrial plasticity negatively impacts hepatocellular carcinoma development in the context of MAFLD”. Manuela Hidalgo (Instituto de Investigaciones Biomédicas Sols-Morreale. IIBM (CSIC-UAM)) | 4. “Mitochondrial strategies to extend healthspan: lessons from the oocyte”. Aida Rodríguez Nuevo. (Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology) | 5.”''The Role of Mitofusin-2 in the Metabolic Adaptation of Skeletal Muscle”. Shrestha Mohapatra (Department of Biochemistry and Physiology, School of Pharmacy and Food Sciences, University of Barcelona)

1.”Identification of a novel ASC-dependent inflammasome inhibitor”. Iván Fernández Pérez. (CIPF) | 2.”Endoglin (CD105) overxpression drives immunosuppressive conditions in the tumor microenvironment of mice”. Claudia Ollauri Ibáñez. (USAL. IBSAL) | 3.”Palbociclib increases the occurrence of the cellular cannibalistic programme entosis in breast cancer”. Federico Lucantoni. (CIPF) | 4.”Small extracellular vesicles (sEV): key players in paracrine senescence”. Sergio Lucio Gallego (CICA. INIBIC)

1.”Lipid-mediated control of collagen secretion”. Yaiza R. Varela Fernández (CSIC, UPV/EHU) | 2.”The Pseudomonas aeruginosa effector Tse5 forms membrane pores disrupting the membrane potential of intoxicated bacteria”. David Albelsa Jové. (UPV/EHU, CSIC) | 3.”Restoring Susceptibility to β-Lactam Antibiotics in Methicillin-Resistant Staphylococcus aureus”. Vega Miguel Ruano. (IQF) | 4.”Identification of a novel fold in the H₂S-producing cystathionine β-synthase enzyme from multidrug-resistant Pseudomonas aeruginosa”. Carolina Conter (CIC bioGUNE, BRTA)

1.“Enhancing Gene Delivery to Human Mesenchymal Stem Cells: Functionalizing Polyethyleneimine with Aldehydes for Improved Transfection Efficiency and Biosafety” Diego Miranda Balbuena (Centro Interdisciplinar de Química y Biología, Coruña) | 2.“Use of human mesenchymal stem/stromal cells to rescue the functional defects of cells from Rett syndrome patients”. María Luisa Molina Gallego (Instituto de Neurociencias UMH-CSIC, Alicante) | 3.“Personalized medicine for ALS by using novel synthetic editing systems – SynCas”. Claudia Carrascal Vento. Fundación Hospital Universitario 12 de Octubre,Madrid) | 4.”Peptides inhibiting isoforms phospholipase C beta show a potential anti-inflammatory activity”. Jorge de Andrés López (IDiBE, Elche)

1.”Small RNA cargo of circulating extracellular vesicles, deciphering the hallmarks of aging”. Carmen Raez Meseguer (TERCIT-IUNICS) | 2.”Biocompatibility and antibacterial efficacy of xanthones: structural influence on in vitro biological activity in human gingival fibroblasts and Porphyromonas gingivalis”. Ana Rodríguez Fernández (TERCIT-IUNICS) | 3.”Targeting oncogenic TRIB2 with small molecules in melanoma”. Wolfgang Link (IIBM) | 4.”First-generation PORTACS for progerin as a new therapeutic opportunity for progeria”. Marcelino Telechea Fernández (UCM)

1.”Targeting Key Drivers of Pseudomonas aeruginosa Pathogenesis in Cystic Fibrosis Bronchial Epithelia”. Carmen Mesas Vaz (UAB) | 2.”Inhibition of bacterial conjugation applying cationic Solid Lipid Nanoparticles”. Oihane Altube (UPV/EHU) | 3.”Resveratrol targets G-quadruplexes to exert its pharmacological effects”. José A Garcia Salcedo (GENYO) | 4.”RNAPII-facilitated repair of ribosomal DNA breaks in nucleolar caps guards against genomic instability”. Daniel Gómez Cabello (US-IBiS)