12:00
13:00
Simposio RAICEX. Tackling immunological challenges with state-of-the-art techniques
Auditorio
Moderador: Rodrigo García (Presidente de RAICEX)
12:00
12:20
Defining intestinal immunopathophysiology: microscopic colitis as a model of low-grade destruction in inflammatory bowel disease
Celia Escudero Hernández
(Instituto de Biomedicina y Genética Molecular de Valladolid (IBGM), CSIC, Valladolid, España)
12:20
12:40
High-throughput drug-repurposing screen identifies FAK as a potential modulator of the suppressive functions of regulatory T cells
Nuria García Díaz
( Institute for Cancer Research, Oslo University Hospital, Oslo, Norway )
12:40
13:00
High-throughput characterization of allergen three-dimensional epitopes using yeast-display
Esperanza Rivera de Torre
(Center for Antibody Technologies, DTU, Bioengineering, Denmark)
09:00
11:00
Simposio 1
S1.1. Hispano-Luso Symposium. Aging, Cancer and Telomeres: Mechanisms and Therapeutic Frontiers
Auditorio
Modera: María Blasco (CNIO, Madrid, España)
09:00
09:30
Targeting telomeres in cancer and aging.
María Blasco
(CNIO, Madrid, España)
09:30
10:00
Telomerase, Inflammation, and Intergenerational Relationships: Insights into Rejuvenation
María Luisa Cayuela
(Instituto Murciano Investigaciones Biosanitarias - Pascual Parrilla-CIBERER, Murcia, España)
10:00
10:30
Alternative Telomere Fusions In Cancer
Ignacio Flores
(CBM, Madrid, España)
10:30
11:00
Glycans in cancer: from biosynthesis to cellular function and clinical implications
Ana Magalhães
(ICBAS/i3S, University of Porto, Porto, Portugal)
09:30
11:00
Simposio 2
S2.1. The Heart at the Core: Novel Insights into Cardiovascular Pathophysiology
Sala Malinche
Modera: Pilar Martín (CNIC, Madrid, España)
09:30
10:00
T cell-derived non coding RNA in inflammaging and metabolic imbalance
Pilar Martín
(CNIC, Madrid, España)
10:00
10:30
T cell immune responses involved in cardiac pathophysiology
Pilar Alcaide
(Tufts University School of Medicine, Boston, MA, USA)
10:30
11:00
Intercellular communication in the inflammatory response
Francisco Sánchez Madrid
(UAM, Madrid, España)
09:30
11:00
Simposio 3
S3.1. Autophagy in Human Diseases
Sala García Matos
Modera: Patricia Gómez Suaga (Facultad de Enfermeria y Terapia Ocupacional. UEx, Cáceres, España)
09:30
10:00
A new role for autophagy machinery in repeat expansion diseases
Patricia Gómez Suaga
(Facultad de Enfermeria y Terapia Ocupacional. UEx, Cáceres, España)
10:00
10:30
Role of mTORC1 in the progression to T2DM
Carlos Guillén Viejo
(Facultad de Farmacia, UCM, Madrid, España )
10:30
11:00
Proteostasis mechamism in glia-neuron communication in neurodegenerative diseases
María Jiménez Sánchez
( King's College London, Reino Unido)
09:30
11:00
Simposio 4
S4.1. Molecular genetic mechanisms of plant development, evolution and adaptation
Sala Europa
Modera: Pilar Cubas (Centro Nacional de Biotecnología-CSIC, Madrid, Spain)
09:30
10:00
Sleeping buds, surviving plants: axillary bud dormancy, a dynamic strategy for plant adaptation to environmental change
Pilar Cubas
(Centro Nacional de Biotecnología-CSIC, Madrid, Spain)
10:00
10:30
Multisensory integration during plant terrestrialization
Miguel Blazquez
(Instituto de Biología Molecular y Celular de Plantas, CSIC-Universitat Politècnica de València, Spain)
10:30
11:00
Revisiting flower development in the light of the LFY-UFO interaction
François Parcy
(Laboratoire Physiologie Cellulaire et Végétale, Université Grenoble Alpes, CNRS, France)
09:00
10:30
Simposio 1
S1.2. Nutrient signaling – from signaling transduction to disease
Auditorio
Modera: Alejo Efeyan (CNIO, Madrid, España)
09:00
09:30
Dissection of the molecular effects of dietary restriction regimes
Alejo Efeyan
(CNIO, Madrid, España)
09:30
10:00
Metabolic control of TORC1
Claudio de Virgilio
(University of Fribourg, Suiza)
10:00
10:30
Metabolic imbalance as a therapeutic strategy in cancer
Raúl V. Durán
(CABIMER, Sevilla, España)
09:00
10:30
Simposio 2
S2.2. DNA break repair in the CRISPR era
Sala Malinche
Modera: Felipe Cortés Ledesma (CNIO, Madrid, España)
09:00
09:30
A comprehensive catalog of human double-strand break repair and CRISPR-Cas9 gene editing
Felipe Cortés Ledesma
(CNIO, Madrid, España)
09:30
10:00
Genome organization in genome maintenance and mutagenesis
Evi Soutoglou
(GDSC, University of Sussex, Reino Unido)
10:00
10:30
Using combinatorial CRISPR/Cas12 edits and mutational signatures to study genetic interactions in DNA repair pathways
EMBO Young Investigator Lecture
Fran Supek
(BRIC/UCPH Copenhagen (DK) and IRB Barcelona (ES))
09:00
10:30
Simposio 3
S3.2. Application of Cutting-edge Proteomics in Biomedical and Clinical Research
Sala García Matos
Modera: Emilio Camafeita (CNIC, Madrid, España)
Modera: María Gómez Serrano (Institute for Tumor Immunology, Philipps University, Marburg, Alemania)
09:00
09:30
“Inside out”: our experience on subcellular and extracellular proteomics of adipose cells
María Gómez Serrano
(Institute for Tumor Immunology, Philipps University, Marburg, Alemania)
09:30
10:00
State-of-the-art approaches for the proteome-wide unbiased analysis of posttranslational modifications in biomedical research
Inmaculada Jorge
(CNIC, Madrid, España)
10:00
10:30
Strategies for Translational Proteomics in Biofluids In Spite of Massive Dynamic Protein Concentration
Johannes Graumann
(Institute of Translational Proteomics and Core Facility Translational Proteomics, Philipps University, Marburg, Alemania)
09:00
10:30
Simposio 4
S4.2. Advances and Challenges in Structure-Based Drug Discovery
Sala Europa
Modera: Armando Albert (Instituto Química Física Blas Cabrera, CSIC, Spain)
09:00
09:30
Cryo-EM and computational biology of GPCRs: accelerating the development of better drugs
Chris Tate
(MRC Laboratory of Molecular Biology, Cambridge, Reino Unido)
09:30
10:00
Faster, Larger, Better XChem: Fast Forward Fragments for progressing fragment hits
Jasmin Aschenbrenner
(Centre for Medicines Discovery, University of Oxford, Oxford, UK)
10:00
10:30
Drugging Plants: Leveraging Structure-Based Strategies to Develop Crop-Enhancing Solutions for Global Warming Resilience
Armando Albert
( Instituto Química Física Blas Cabrera, CSIC, Spain)