1.” MUC13 as a potential tumor marker and therapeutic target for the treatment of pseudomyxoma peritonei” Mari C. Vázquez Borrego (Universidad de Córdoba, Córdoba, España) | 2.” Fabp5 as a novel nephroprotective factor in acute kidney injury” Noelia Molina Cazallas (Instituto de Investigación Sanitaria Fundación Jiménez Díaz (IIS-FJD), Madrid, España) | 3.” Deciphering the role of TMOD2 as a metastatic colorectal cancer biomarker” Sofía Jiménez De Ocaña (Chronic Disease Programme (UFIEC), Instituto de Salud Carlos III, Madrid, Madrid, España) | 4.” Mechanisms underlying vascular impairment in COPD: new unsuspected role of nAChR” María Calzada García (Universidad Autónoma de Madrid, Madrid, España) | 5.” Showing EVidence: unravelling adipose tissue and breast cancer crosstalk” Alejandro Pinedo Serrano (Instituto de Biomedicina, Universidad de Castilla-La Mancha, Albacete, España) | 6.” MITF-Dependent Target Analysis in Gastrointestinal Stromal Tumors and Its Implications in Autophagy and Extracellular Vesicle Secretion” Margarita Martín Andorrà (Universitat de Barcelona, Barcelona, España)

1.” In-depth proteomic profiling of FFPE tumour tissues and plasma extracellular vesicles reveals differential protein expression associated with ColoRectal Cancer recurrence” Raquel Rejas González (Instituto de Salud Carlos lll, Madrid, Madrid, España) | 2.” Effect of the brain microenvironment on the stem-like properties of cancer stem cells: phosphoproteomic of cancer stem cells in brain metastasis” Jesús Gómez Escudero (Universidad de Salamanca, Salamanca, España) | 3.” Reprogramming of Kupffer cells in lipotoxic environment during metabolic associated fatty liver disease” Clara Bonacasa Escrich (Centro Nacional de Investigaciones Oncológicas (CNIO), Madrid, España) | 4.” Spatial lipidomics of midbrain dopaminergic neurons reveals early metabolic changes in a Parkinsonian mouse model”Alejandro Jiménez Medina (Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Sevilla, España) | 5.” The RNA editing damage response as a driving force of tumour adaptation” Lucía González López (Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER), Sevilla, España)

1.”The Impact of p38 MAPK Signaling on CD8+ T Cell Function and Immune Regulation” Irene Ruiz Garrido (Centro Nacional De Investigaciones Cardiovasculares, Madrid, Madrid, España) | 2.” Different cooperativity between MAPK and PI3K signaling activation in GL261 cells and their neurospheres” Lucía García Gómez (Universidad de Salamanca, Salamanca, Salamanca, España) | 3. “SUCNR1 Signaling Promotes Breast Cancer Progression through Metabolic Modulation” Noelia Pelaez Poblet (Department of Endocrinology and Nutrition, Research Unit, Institut d'Investigació Sanitària Pere Virgili (IISPV), Hospital Universitari de Tarragona Joan XXIII, Tarragona, Tarragona, España) | 4.” Role of Cancer-Associated Fibroblasts in Photodynamic Therapy response in Oral Squamous Cell Carcinoma spheroid models” Andrea Barahona Lopez (Universidad Autónoma de Madrid, Madrid, Madrid, España) | 5.” Mitochondrial DNA as a Signaling Molecule in Lung Adenocarcinoma: Implications for Inflammation and Oncogenesis” Rafael Garrido Fernández (MitoPhenomics Lab, Centro Singular de Investigación en Medicina Molecular y Enfermedades Crónicas (CiMUS), Santiago De Compostela, La Coruña, España) | 6.” Acute oxygen sensing by Ca2+ channels in resistance pulmonary arteries depends on mitochondrial complex I function” Ibrahim Benzoura (Instituto de Biomedicina de Sevilla (IBIS), Hospital Universitario Virgen del Rocío, CSIC, Universidad de Sevilla, Sevilla, España)

1.”SARS-CoV-2 ORF7a and ORF7b drive distinct mechanisms of endothelial dysfunction in COVID-19” Tránsito García García (Department of Genetics, Immunogenomics and Molecular Pathogenesis Group, UIC Zoonoses and Emergent Diseases ENZOEM, University of Córdoba, Córdoba, España) | 2.”Disbiosis Microbiana por Obesidad: Reprogramando el Cáncer de Endometrio” Lucía Aranega Martín (Departamento de Especialidades Quirúrgicas, Bioquímica e Inmunología. Facultad de Medicina, Universidad de Málaga; Grupo de Investigación Clínica y Traslacional en Cáncer, Unidad de Oncología Médica del Hospital Virgen de la Victoria, Instituto de Investigación Biomédica de Málaga (IBIMA), Málaga, España) | 3.” Single-Cell Transcriptomic Dissection of Immune and Metabolic Rewiring in the Porcine Ileum During Salmonella Typhimurium Infection” Sara Zaldívar-López (Immunogenomics and Molecular Pathogenesis Group, UIC Zoonosis and Emergent Diseases ENZOEM, Department of Genetics, University of Córdoba, Córdoba, España) | 4.” The receptor binding domain of the parvovirus Minute Virus of Mice capsid in anti-cancer applications” Alejandro Fernández Llorente (Centro Biología Molecular Severo Ochoa, (CSIC-UAM), Departamento de Biología Molecular, Universidad Autónoma de Madrid, Madrid, España)

Repertorio: "Vilja's Lied" (Franz Lehar)

Repertorio: "Adieu" (Poème d'un jour - G.Faure ) | "O mio babbino caro" (G. Puccini)

Cada entidad dispondrá de 5 minutos para exponer sus planes, seguidos de una Mesa de discusión y ronda de preguntas.

1.”E2F1 is required for Hippo signaling-driven cholangiocarcinoma by regulating mitochondrial lipid metabolism” Kendall Alfaro-Jiménez (University of the Basque Country (UPV/EHU), Faculty of Medicine and Nursing, Department of Physiology, Leioa, Vizcaya, España) | 2.”Efectos del FGF23 sobre la inflamación en riñón y páncreas en un modelo murino de obesidad inducida por dieta” Ainhoa González Luis (Universidad de La Laguna, La Laguna, Santa Cruz de Tenerife, España) | 3.”Unraveling the role of Retinoid-related Orphan Receptor gamma (RORγ) in the response of adipocytes to calorie restriction by using a novel adipocyte-specific inducible Rorc knockout mouse model” Laura Hidalgo Corbacho (Vall d’Hebron - Institut de Recerca, Barcelona, España) | 4.”Distinct mutational landscapes drive specific metabolic rewiring in HCC shaping differential responses to feeding a high-fat diet” Natalia Sainz-Ramírez (Physiology Department; Medicine and Nursery Faculty; University of the Basque Country, UPV/EHU, Leioa, Vizcaya, España) | 5.”Emerging Role of Extracellular Vesicles in Postprandial Inter-Organ Communication and Metabolic Adaptation in Obesity” Miriam Gutiérrez Gala (Research Unit, University Hospital of Tarragona Joan XXIII – Institute of Health Research Pere Virgili (IISPV), Tarragona, España) | 6.” C3G deletion alters liver metabolism and glucose homeostasis” Jaime Mancebo (Departamento de Bioquímica y Biología Molecular, Facultad de Farmacia, Universidad Complutense de Madrid, Madrid, España)

1.” Lmx1b regulation during limb development” Marian Ros Lasierra (Instituto de Biomedicina y Biotecnología de Cantabria, Santander, Cantabria, España) | 2.” Retinoid X Receptors as Transcriptional Regulators of Tissue-Resident Macrophages: Kupffer Cells” Laura Casablanca Osorio (CNB-CSIC, Madrid, España) | 3. “Unraveling the role of Bud27 in ribosomal DNA transcription in Saccharomyces cerevisiae” Jorge Pérez Fernández (Universidad de Jaén, Jaén, España) | 4.” A dCas9/R-loop replication obstacle defines different mechanisms of recombinational bypass at the leading and lagging strand” Macarena Alcalá Domínguez (Centro Andaluz de Biología Molecular y Medicina Regenerativa –CABIMER, Sevilla, España) | 5.” Precise Gene Editing of Pathogenic Lamin A Mutations Corrects Cardiac Disease” Xurde Caravia (UT Southwestern Medical Center, Dallas, Estados Unidos) | 6.” In-depth analysis of the mode of action of resveratrol: genome-wide characterization of G-quadruplex binding properties” Ana Soriano Lerma (GENYO. Centre for Genomics and Oncological Research: Pfizer / University of Granada / Andalusian Regional Government, Granada, España)

1.” Reprogramming of muscle p38 signalling as a pathway to better ageing” Alfonso Mora Corral (Centro Nacional de Investigaciones Oncológicas (CNIO), Madrid, Madrid, España) | 2.” "Anticancer activity of dietary polyphenols curcumin, epigallocatechin gallate, oleuropein and quercetin through induction of apoptosis, senescence, cell cycle arrest and telomeric damage in NSCLC models" Ana Jiménez Gordo (Telomeres and Tumor Microenvironment Unit, Fundación Rioja Salud-CIBIR, Logroño, La Rioja, España)| 3. “Dietary anthocyanins exhibit anticancer activity through induction of apoptosis, senescence, cell cycle arrest and telomeric damage in lung cancer cells and xenograft models" Elvira Alfaro Arnedo (Instituto de Ciencias de la Vid y del Vino (ICVV), Consejo Superior de Investigaciones Científicas (CSIC)-Universidad de La Rioja-Gobierno de La Rioja, Logroño, La Rioja, España) | 4.” Low-Dose Melatonin Partially Rejuvenates Senescent C2C12 Myoblasts by Restoring Autophagy” Ignacio Vega Naredo (Universidad de Oviedo, Oviedo, Asturias, España) | 5.” Decoding the cellular senescent microenvironment dialogue within human skeletal muscle degeneration during sarcopenia” Eduardo Antuña (Research Group OSKAR, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Asturias, España) | 6.” Senotoxins: A Novel Strategy to Target Chemotherapy-Induced Senescence” Isabel Fernández Carrasco (IMDEA Food Institute, Madrid, España)

1.” Rapid stem cell spreading induced by high affinity α5β1 integrin-selective bicyclic RGD peptide in biomimetic hydrogels. Guillermo Solís Fernández (Molecular Imaging and Photonics Division, Department of Chemistry, KU Leuven, Leuven, Bélgica) | 2.” Understanding the significance of arachidonic acid (AA) in the main pancreatic fibrosis originator, the pancreatic stellate cells” Cándido Ortíz Placín (University of Extremadura, Cáceres, España) | 3.” Mucins impact in clear cell Renal Cell Carcinoma (ccRCC) aggressiveness” Gerardo Cantero Recasens (Vall d'Hebron Research Institute, Barcelona, España)

1.” Molecular characterization and functional role of serpins in hepatocellular carcinoma” María Serrano Jiménez (Maimonides Institute for Biomedical Research of Cordoba (IMIBIC), 14004-Cordoba, Spain., Córdoba, España) | 2.” Impact of Adipose Tissue on Breast Cancer Development” Alba Concepción Arcones (CNIO, Madrid, España) | 3.” Hyperglycemia-Induced Disruption of Pyrophosphate Metabolism Promotes Vascular Calcification in Diabetes” Alicia Flores Roco (Centro Singular en Investigación en Medicina Molecular y Enfermedades Crónicas (CiMUS). Campus Vida. Universidad de Santiago de Compostela., Santiago De Compostela, La Coruña, España)

EMBO Young Investigator Lecture

1.” Unveiling the structure of USP proteins in Archaea” María-José García Bonete (Universidad de Alicante, Alicante, España) | 2.”Structural insights into choline translocation through SLC5A7/CHT” Adrián Martínez Jiménez (Universitat de Barcelona, Barcelona, España) | 3.” From plant to patient: Functional diagnosis of ∆¹-pyrroline-5-carboxylate synthetase (P5CS) deficiency using the plant enzyme” Sara Pla Fanjul (Centro para Investigación Biomédica en Red sobre Enfermedades Raras CIBERER-ISCIII, Valencia, España) | 4.” Beyond the cell cycle: the atypical cyclin CCNP regulates innate immune signaling and viral replication” Eva Quandt Herrera (Universitat Internacional de Catalunya, Sant Cugat Del Valles, Barcelona, España)

1.”miRNA study highlights the impact of Wnt pathway on familial hypomagnesemia with hypercalciuria and nephrocalcinosis (FHHNC) severity” Julieta Torchia Pruzzo (Vall d´Hebron Institute of Research, Barcelona, España) | 2.” Structural characterization of the sensor domain of RcsD” Ignacio Francés Castillo (Instituto de Biotecnología y Biomedicina (BIOTECMED), Universidad de Valencia, Valencia, España) | 3.” EV-based mRNA therapy as a novel approach for TNBC” Rebeca Martínez Martínez (CINBIO, Vigo, Pontevedra, España) | 4.” New Peptides Inhibiting the Activity of CPT1A and CPT1B enzymes as Potential Antitumor Agents” Mercè Gómez Pallarès (Universitat Internacional de Catalunya (UIC), Sant Cugat Del Valles, Barcelona, España) | 5.” Generation of a mouse model to study Citrin Deficiency” Ismael Garcia Lobo (Instituto Universitario de Biología Molecular, (IUBM) and Centro de Biología Molecular Severo Ochoa, Madrid, España)

1.” Sulforaphane as a Therapeutic Strategy in SLC25A38-Linked Congenital Sideroblastic Anemia: Targeting NLRP1 Inhibition” Ana Belén Pérez Oliva (Biomedical Research Institute of Murcia (IMIB)-FFIS, Murcia, España) | 2.” From Alveolar Inflammation to Cardiac Dysfunction: Effects of Environmental Pollution on Porcine Cell Cultures” Darío Mandaglio Collado (Department of Cardiology, Hospital Clínico Universitario Virgen de la Arrixaca, University of Murcia, Instituto Murciano de Investigación Biosanitaria (IMIB-Arrixaca), CIBERCV, Murcia, España) | 3.”Role of Inflammasome Activation and Cell Death Mechanisms in β- Thalassemia” Ana María Conesa Hernández (Departamento de Biología Celular e Histología, Facultad de Biología, Universidad de Murcia, Murcia, España) | 4.” Maraviroc intensification reduces persistent inflammation in people living with HIV” Sergio Calderón Vicente (Infectious Diseases Department, Hospital Universitario Ramón y Cajal, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid, España) | 5.” Exploiting Connexin 43 to Enhance NK Cell-Mediated Antitumor Immunity” Alexander Carneiro Figueira (CINBIO, Vigo, Pontevedra, España) | 6.” Impact of Lipin-2 Deficiency on Metabolic and Signaling Events during Macrophage Polarization” Laura Valerio Núñez (Instituto de Biomedicina y Genética Molecular (IBGM), CSIC-UVa, Valladolid, España)

1.” Acriflavine treatment of patient-derived primary cultures uncovers the therapeutic potential of dual HIF-1α and HIF-2α inhibition in VHL-associated hemangioblastomas” Blanca Yélamos (Servicio de Salud de Castilla-La Mancha (SESCAM), AAlbacete, España; Instituto de Investigación Sanitaria de Castilla-La Mancha (IDISCAM), Toledo, Toledo, España) | 2.”E2F4, a new multifactorial therapeutic target for Alzheimer’s disease: its role as synaptic regulator” Alberto Fraj-Cebrián (Instituto Cajal (CSIC), Madrid, España) | 3.” Role of the glycine transporter GlyT2 in the neuronal differentiation of PC12 cells” Jorge Sarmiento Jiménez (Departamento de Biología Molecular. Instituto de Biología Molecular (IUBM). Centro de Biología Molecular “Severo Ochoa,” Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid, España) | 4.” Neuroprotective Transcriptomic Responses in SH-SY5Y Cells Induced by Bioavailable Compounds from Red Grape Skins” Gisela Gerardi (Universidad de Burgos, Burgos, Burgos, España) | 5.” Modeling HSV-1-Induced Alzheimer's Pathology in Human 3D Neural Spheroids” María Martín Rico (Centro de Biología Molecular Severo Ochoa, Madrid, Madrid, España) | 6.” NOX4 Deficiency Accelerates Age-Related Hearing Loss and Cochlear Degeneration in Mice: Insights from a Knockout Model” Marina Tapias Martin (Institute for Biomedical Research “Sols-Morreale”, Spanish National Research Council – Autonomous University of Madrid (CSIC-UAM), Madrid, Madrid, España)

1.”Mitochondrial Function In Colorectal Cancer: Implications for the Diagnosis, Surgery and Treatment of Colorectal Cancer” María Monsalve (Sols-Morreale Biomedical Research Institute (IIBM, CSIC-UAM), Madrid, España) | 2. “Mitochondrial protein MCJ as a modulator of chronic inflammation in obesity” Javier Pérez-García (Spanish National Cancer Research Center (CNIO), Madrid, España) | 3.” Disrupting GSH homeostasis and NADPH oxidase activity as a potential therapeutic strategy in acute myeloid leukaemia” Clara García-Calvo (Universidad de Salamanca, Salamanca, España) | 4.” Changes Induced by type 2 sodium-glucose cotransporter inhibitors (SGLT2i) in Lymphocytes from Diabetic Kidney Disease patients” Andrea Raposo López-Pastor (Laboratory of Genetics and Molecular Bases of Complex Diseases, Health Research Institute of Hospital Clinico San Carlos (IdISSC), Madrid, España) | 5.” Can an acorn cupule extract restore mitochondrial quality in Parkinson's disease models?” Nerea Domínguez Rojo (Departamento de Bioquímica y Biología Molecular y Genética, Facultad de Enfermería y Terapia Ocupacional, Universidad de Extremadura, Cáceres, España) | 6.”The cellular energy status in primary endothelial cells modifies Nrf2 and Foxo3-dependent antioxidant regulation” Leticia Selinger Galant (Biomedical Research Institute Sols-Morreale (IIBM), Madrid, España)

1.” Lung Surfactant as an Interfacial Highway for Nanomedicine” Gloria Gómez-Montesino (Universidad Complutense de Madrid, Madrid, España) | 2.” A non-canonical membrane remodeling function detected for Dynamin 2” Irune Ornos García (Instituto Biofisika (CSIC, UPV/EHU), Leioa, Vizcaya, España) | 3.” Investigating the Role of the Transmembrane Domain in ROR1 Dimerization” Luis Jesús Baeza Ballesteros (Universitat de Valencia, Valencia, España) | 4.” New biomarker based on a membrane protein in synovial fluid for early diagnosis of Osteoarthritis” Iñaki López Díaz (CELLCOM Research Group, Biomedical Research Center (CINBIO), Edificio Olimpia Valencia, Campus Universitario Lagoas Marcosende and Galicia Sur Health Research Institute (IIS Galicia Sur), Vigo, Pontevedra)

1.”Physicochemical, Antioxidant and Antimicrobial Characterization of Salvadora persica Bark Extracts from Morocco: Insights into Their Oral Health Potential” Yasmine Elaoulabine (Faculty of Medicine and Pharmacy, Rabat, Marruecos) | 2.” Cytotoxic studies of cyclometalated Pt(IV) complexes with phenanthroline-based ligands” Icíar P López Cibir (Lung Cancer and Respiratory Diseases Unit, Center for Biomedical Research of La Rioja (CIBIR), Fundación Rioja Salud, Logroño, La Rioja, España) | 3.” Biochemical approach for the characterization of Natterin-like 2 from Thalassophryne maculosa venom. Evidence of a serine protease like” Aleikar Vásquez Suárez (Aleikar Vásquez Suárez) | 4.” Protein–Drug Interaction Profiling of Titanocene Complexes: Influence of Aliphatic Chain Structure on Albumin Binding” Alicia Maldonado Medina (Universidad de Castilla-La Mancha, Toledo, España) | 5.”Photodynamic Therapy as a Promising Alternative for Oral Cancer in Fanconi Anemia Patients Cells” Marta Mascaraque Checa (Universidad Autónoma de Madrid, Madrid, España)

1. “Plasmid curing or mutation suppression with essential oils requires the expression of the colistin resistance determinant” José Luis Píriz (Department of Biochemistry, Molecular Biology and Genetics, Faculty of Veterinary Medicine, University of Extremadura, Cáceres, España) | 2.” Unveiling the role of All0345, a novel transcriptional regulator of the FurC (PerR) regulatory network, in the nitrogen metabolism in Anabaena sp. PCC 7120” Marta Acero Enguita (Department of Biochemistry and Molecular and Cellular Biology, University of Zaragoza, Zaragoza, España) | 3.” Identification of a Novel Aldehyde Dehydrogenase in the Furfural Assimilation Pathway” Faustino Merchan Sorio (Universidad de Extremadura, Cáceres, España) | 4.” Combinatorial analysis of photobioreactor geometry and nitrogen availability for astaxanthin accumulation in the green algae Haematococcus pluvialis” Julia Esclapez Espliego (Dpto. Bioquímica y Biología Molecular y Edafología y Química Agrícola. Universidad de Alicante, Alicante, España) | 5.” A new approach to lindane bioremediation: coculturing plants with Anabaena PCC712” Giuliana Morabito Polola (Universidad de Zaragoza, Zaragoza, España) | 6.” Intraspecific Natural Variation in Terpene Profiles and Their Association with Antifungal and Antioxidant Activity of Essential Oils from Eucalyptus globulus and E. camaldulensis” Freddy Mora-Poblete (Institute of Biological Sciences, University of Talca, Talca, Chile)